Anthelmintic Action Type

treat

Tetraneem is administered by different routes of administration, and it has a therapeutic effect on animals poisoned by botulinum toxin; for mice given a lethal dose of botulinum, the survival rate of Tetraneem is up to six hours after the challenge. More than 80%; treatment for botulism monkeys after 24 hours of challenge can cure more than half; it also has a protective effect on type C botulism. Combination with anti-toxin serum can significantly reduce the amount of anti-toxin serum. The botulism-induced mice had a significant antagonistic effect on the reduction of synaptic vesicles in the neuromuscular junction of the diaphragm caused by lilytridin. Experiments have shown that the density of synaptic vesicles in the synaptic area of the neuromuscular junction in normal mice is 184±37цm2/given only after tetrahydropyranin is given, the synaptic vesicles in the neuromuscular junction are significantly reduced, and the average density is 68±15/um2. The average density of mice that were given toxin after toxin were 137±18/μm2 and 130±26/μm2, respectively, which has certain significance for further exploration of the mechanism of action of lignephrin and botulinum toxin.

Antifungal

The water extracts of neem bark, junzi, and betel nut have inhibitory effects on certain skin fungi in the test tube.

Gallbladder excitement

Betelnut injection can obviously excite the gallbladder muscles in guinea pigs or in vivo gallbladders of cats and dogs, causing powerful contraction and increasing the excretion of gallbladder contents. No obvious effect on bile secretion. Rhubarb injection can promote bile secretion. If the two are used intermittently, it can increase the pressure of the common bile duct in a short time for dogs or cats, accelerate the discharge of bile, and facilitate the discharge of common bile duct stones. Betel nut has a certain contraction effect on the human gallbladder, which is weaker than that of dogs. It is clinically compatible with other Chinese medicines and can promote the excretion of biliary roundworms or stones. Betel nut has a cholinergic effect, which is similar to pilocarpine and muscarinic. It excites M choline receptors and also has a cholinergic effect on the central nervous system. Intravenous injection of a small amount of arecoline in cats can cause cortex In wakefulness response, atropine can reduce or block this effect. Arecoline also has the effect of stimulating N-choline receptors.

Toxic effect

Several anthelmintics

Several anthelmintics (5 photos)

Neem bark decoction can cause vomiting in dogs at 15 g/kg, and the lethal dose to rabbits is more than 40 g/kg. The tolerance of animals may vary slightly due to nutritional status and physical fitness. Chuanmusu is administered to dogs and cats by intragastric administration in different doses. The blood pressure decrease can increase with increasing dose, blood pressure can drop to zero sharply, breathing and heartbeat stop, lung and gastrointestinal bleeding. Microscopic examination revealed that the bleeding was caused by damage to the blood vessel wall. The respiratory failure was mainly caused by the direct inhibition of the respiratory center. Nicosamide had a slight antagonistic effect on the respiratory depression caused by it. Subacute toxicity experiments show that Chuanzhong can increase glutathione in mice and monkeys. The pathological changes of the liver are more obvious than other organs, and there are brown-yellow particles deposited on the vascular intima. Pigs poisoned by the oral administration of Chuanmeisu tablets showed tremor of limbs, violent movement, and paroxysmal convulsions. Poisoned children show unsteady standing, delirium, lethargy, dilated pupils, slow response to light, etc., which may be related to the purity of the drug, dosage form and animal species.

Toxic doses of ligneidin can cause general weakness (paralysis, drooping head, drooping eyelids), difficulty breathing, and twitching of the limbs in rats, pigs, dogs and monkeys.

Experiments have proved that Chuanzhong is a neuromuscular transmission blocker that selectively acts on the presynaptic membrane. It can block the normal transmission between the nerves and muscles of rats and mice, which is the direct cause of muscle weakness in monkeys and other animals. Electron microscopic observations showed that Tetranead had significant changes in the submicroscopic structure of the presynaptic membrane of neuromuscular junctions in mice and rats.

Subcutaneous injection in mice made the minimum lethal dose of Gentleman Water Extract 20g/kg, causing mild convulsions throughout the body, and then breathing stopped, making Gentleman oral 26.6g/kg to the dog, which can cause vomiting and dysphoria. Arecoline can enhance gastrointestinal peristalsis and cause diarrhea. Gastrointestinal cramps, severe abdominal pain, nausea, vomiting and other symptoms often occur.