1. Name and Identification

The active pharmaceutical ingredient is Carbasalate Calcium, identified by its CAS No. 5749-67-7. It is a highly water-soluble complex of acetylsalicylic acid and urea with calcium salt, widely recognized for its anti-inflammatory, antipyretic, and analgesic properties.

2. Chemical Characteristics

Carbasalate Calcium functions primarily by inhibiting prostaglandin synthesis through irreversible acetylation of cyclooxygenase (COX) enzymes. This mechanism reduces pain, inflammation, and fever, making it effective for symptomatic relief in various animal conditions. Its unique complexation enhances stability and solubility compared to pure acetylsalicylic acid.

3. Physical Properties

Carbasalate Calcium typically presents as a white crystalline powder. A key advantage is its high solubility in water, allowing for easy dissolution and uniform dispersion in drinking water systems for livestock. It maintains excellent stability under recommended storage conditions, ensuring consistent quality for pharmaceutical manufacturers.

4. Quality Specifications and Standards

5. Veterinary Applications

Our Carbasalate Calcium is expertly formulated for:

• Symptomatic treatment of fever, pain, and inflammation associated with various infectious diseases in poultry, pigs, and calves.
• Alleviation of discomfort and support during respiratory diseases (e.g., BRD, SRD) and gastrointestinal disturbances.
• Reduction of fever following vaccination or during periods of environmental stress.
• Use in highly soluble oral powders or solutions for easy administration through drinking water or mixed with feed.
• Improving feed intake and overall well-being in sick or stressed animals.

Pharmacological Actions in Animal Health

Carbasalate Calcium is a highly effective, soluble NSAID (Non-Steroidal Anti-inflammatory Drug) that plays a vital role in supportive veterinary care due to its potent actions:

• Mechanism of Action: It exerts its anti-inflammatory, antipyretic, and analgesic effects primarily by inhibiting the synthesis of prostaglandins. This is achieved through the irreversible acetylation of cyclooxygenase (COX) enzymes, which are key mediators of pain, inflammation, and fever in animal systems.
• Therapeutic Effects: Rapidly reduces fever associated with various disease states, alleviates pain stemming from inflammatory processes, and mitigates the inflammatory response itself. This multifaceted action improves animal comfort and aids in faster recovery.
• Pharmacokinetics in Animals: Following oral administration (e.g., via drinking water), Carbasalate Calcium is quickly absorbed and then hydrolyzed into its active components, acetylsalicylic acid and salicylic acid. These active metabolites are widely distributed throughout the body, ensuring a rapid onset of symptomatic relief.
• Formulation Suitability: Its superior water solubility makes it an ideal API for oral solutions and soluble powders, facilitating mass administration through drinking water, which is crucial for efficient herd or flock treatment during disease challenges.

Essential Chemical Attributes

• pH in Solution: A 1% aqueous solution of Carbasalate Calcium typically exhibits a pH range of 5.0–7.0, indicating its suitability for stable aqueous formulations.
• Thermal Stability: The crystalline powder demonstrates reliable thermal stability under recommended storage conditions, requiring protection from excessive heat.
• Light Sensitivity: Should be stored in light-resistant containers to prevent potential degradation, preserving its efficacy over time.
• Hygroscopicity: Possesses moderate hygroscopic properties. Containers must be kept tightly sealed to shield the material from moisture absorption and maintain its quality specifications.
• Solubility Characteristics: A key feature is its high solubility in water, forming clear solutions rapidly. This property is crucial for its application in drinking water for livestock.

Targeted Applications Across Animal Species

Our Carbasalate Calcium is a strategic choice for symptomatic support in various animal health scenarios:

• Poultry: Effective in reducing fever and discomfort associated with respiratory diseases (e.g., Avian Influenza, Newcastle Disease) and during periods of heat stress or post-vaccination reactions.
• Pigs: Crucial for alleviating fever and pain in conditions like Swine Respiratory Disease (SRD), swine influenza, and other febrile states, improving appetite and recovery.
• Calves: Valuable for reducing fever and inflammation related to Bovine Respiratory Disease (BRD), scours, and other infectious conditions.
• General: Ideal for mass administration via drinking water or feed, providing efficient and uniform treatment across large groups of animals during outbreaks or stress.

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