Ceftiofur Hydrochloride
Product name: Ceftiofur Hydrochloride
CAS: 103980-44-5
Appearance: A pale yellow to yellow powder
Solubility: Freely soluble in water; practically insoluble in ethanol and in organic solvents.
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Product Introduction
Veterinary-Grade Third-Generation Cephalosporin
Ceftiofur Hydrochloride (CAS: 103980-44-5) is a potent, broad-spectrum cephalosporin antibiotic used extensively in veterinary medicine. It is effective against a wide range of gram-negative and gram-positive pathogens, particularly in respiratory and systemic infections.
Due to its excellent safety profile, low resistance potential, and strong bactericidal effect, Ceftiofur Hydrochloride is widely formulated as injectable suspensions for use in cattle, swine, poultry, and horses.
Broad-Spectrum Activity
Active against respiratory pathogens like Pasteurella, Actinobacillus, and Mannheimia species
Long-Acting Formulations
Used in sustained-release injectable forms, ensuring extended therapeutic levels in plasma
Veterinary Approval
Widely approved and trusted for treating bacterial diseases in food-producing animals
Specification
1. Name and Identification
The active pharmaceutical ingredient is Ceftiofur Hydrochloride (Veterinary Grade), CAS No. 103980-44-5. It is primarily used in parenteral formulations for the treatment of bacterial infections in livestock.
2. Chemical Characteristics
Ceftiofur Hydrochloride is a third-generation cephalosporin with β-lactam structure. It works by inhibiting bacterial cell wall synthesis, leading to cell death.
3. Physical Properties
This substance appears as a pale yellow to light brown powder, hygroscopic, with slight solubility in water. It is stable under recommended storage conditions.
4. Specifications and Standards
| Test Parameter | Specification |
| Appearance | Light yellow to tan crystalline powder |
| Identification | Meets USP/EP requirements |
| Loss on Drying | ≤ 5.0% |
| pH (1% solution) | 3.5 – 5.5 |
| Assay | ≥ 98.0% |
5. Veterinary Applications
Veterinary Ceftiofur Hydrochloride is used in:
- Treatment of bovine respiratory disease (BRD) and swine respiratory disease (SRD)
- Used in equine practice for respiratory tract infections
- Effective in controlling bacterial metritis in dairy cows
- Formulated into injectable suspensions or sterile powders
- Supports reduced use of critical human antibiotics through veterinary stewardship
Properties
Pharmacological Properties in Animal Systems
Ceftiofur Hydrochloride (Veterinary Grade) is a third-generation cephalosporin antibiotic used in veterinary practice for its broad-spectrum and beta-lactamase-resistant activity:
- Mechanism of Action: Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins, leading to cell lysis and death.
- Spectrum of Activity: Active against gram-positive and gram-negative bacteria, including E. coli, Pasteurella multocida, Mannheimia haemolytica, and Salmonella spp.
- Pharmacokinetics in Animals: Administered parenterally; metabolized into desfuroylceftiofur, the active moiety. Provides sustained levels in plasma and tissue.
- Stability in Formulations: Stable in lyophilized and dry powder forms; reconstituted solutions should be used promptly.
Chemical Properties
- pH in Solution: Reconstituted solutions typically have a pH of 4.0–6.5.
- Thermal Stability: Stable when stored in dry form under ambient temperatures; avoid high humidity and heat exposure.
- Light Sensitivity: Light-sensitive; store away from direct sunlight.
- Hygroscopicity: Hygroscopic in nature; should be kept in airtight containers after opening.
- Solubility Characteristics: Freely soluble in water after reconstitution; practically insoluble in most organic solvents.
Applications in Different Animal Species
Veterinary-grade Ceftiofur Hydrochloride is widely applied across animal husbandry sectors:
- Cattle and Ruminants: Used to treat bovine respiratory disease (BRD), foot rot, and postpartum metritis.
- Swine: Indicated for the treatment of swine respiratory disease (SRD) associated with bacterial pathogens.
- Poultry: Used under veterinary supervision for specific bacterial challenges in breeder and layer flocks.
- Equine: Occasionally prescribed for bacterial infections under controlled veterinary care.
Quality Control
Quality Control Measures for Veterinary API
Ceftiofur Hydrochloride is subject to rigorous quality control protocols tailored for veterinary pharmaceutical applications:
Analytical Testing Methods:
- HPLC Analysis: Determines potency, impurities, and stability profile
- UV-Vis Spectroscopy: Assists in identity verification and structural integrity
- Microbial Contamination Testing: Ensures absence of microbial contaminants
- Moisture Determination: Performed via Karl Fischer or gravimetric analysis
- Solvent Residue Analysis: In line with ICH guidelines for safety assurance
Veterinary-Specific Quality Assurance:
Produced under GMP-certified processes. Accompanied by COA, MSDS, and batch-level traceability documentation.
Stability and Compliance:
Validated under accelerated and real-time ICH conditions. Fully compliant with international veterinary standards.
Regulatory and Safety:
- Complies with USP, EP, and veterinary compendial requirements
- Produced in GMP-certified veterinary API facilities
- Full batch release protocols in place before shipment
Packaging & Transportation
We provide moisture-proof and stability-maintaining packaging solutions for Ceftiofur Hydrochloride (Veterinary API), along with flexible transportation modes to support global delivery.
Packaging Options
Veterinary-Grade Packaging
1kg aluminum foil bags: For samples and trial batches
25kg fiber drums: With double PE liners for bulk supply
Custom packaging: Available on request
Pharmaceutical-grade materials: Moisture- and light-resistant, contamination-proof
Transportation Options
Global Logistics Solutions
Express: DHL/FedEx/TNT for urgent or small-volume orders
Air freight: For medium-volume, time-sensitive deliveries
Sea freight: Cost-effective for bulk shipments with full documentation
Dispatch: Ships in 2–3 business days after payment
Company Certifications
Veterinary Compliance & Accreditation
- Veterinary GMP: Manufactured under veterinary Good Manufacturing Practice (GMP) protocols.
- ISO 9001:2015: Certified quality system supporting product consistency and risk reduction.
- ISO 14001:2015: Environmental compliance integrated with sustainability efforts.
- Document Readiness: Includes COA, MSDS, traceability report, and shipping compliance paperwork.
Veterinary GMP
ISO 9001:2015
ISO 14001:2015
FAQ
Frequently Asked Questions About Ceftiofur Hydrochloride
Q1: Can I get a sample of Ceftiofur Hydrochloride?
A: Yes, free samples are available for testing. Customers are responsible for the shipping cost.
Q2: What is the main veterinary application of this product?
A: Ceftiofur Hydrochloride is commonly used to treat bacterial respiratory diseases in cattle, pigs, and horses, including bovine respiratory disease (BRD) and swine pneumonia.
Q3: What is the product's shelf life?
A: The shelf life is 24 months when stored in a tightly sealed container under dry, cool conditions.
Q4: Do you offer DDP delivery?
A: Yes, DDP shipping is available depending on the order volume and delivery country.
Q5: Can you provide full documentation?
A: Yes, we provide COA, MSDS, packing list, commercial invoice, and import-related documents. GMP certificate or WC support can be arranged if required.
Q6: What is the withdrawal period for ceftiofur in meat and milk?
A: Typically, the withdrawal period is 4–7 days for meat and 0–2 days for milk, depending on the dosage and local regulations.
Q7: What class of antibiotic is Ceftiofur Hydrochloride?
A: It belongs to the third-generation cephalosporins, offering broad-spectrum activity against Gram-positive and Gram-negative pathogens.
Q8: What are the common side effects in animals?
A: Ceftiofur is generally well tolerated. Rare reactions may include local swelling at the injection site or mild gastrointestinal upset.
Q9: Can Ceftiofur be used in lactating animals?
A: Yes, but always follow local veterinary guidelines regarding milk withdrawal and permitted use in dairy cows.
Q10: What's the difference between Ceftiofur Sodium and Ceftiofur Hydrochloride?
A: Both have similar antimicrobial effects, but the hydrochloride form has improved stability and longer shelf life, making it preferred for dry formulations.
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