Tilmicosin
CAS:108050-54-0
Appearance:white or off white powder
Purity:≥85%
Molecular formula：C46H80N2O13
molecular weight：869.15
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Product Introduction
Veterinary-Grade Macrolide Antibiotic
Tilmicosin (CAS: 108050-54-0) is a semi-synthetic macrolide antibiotic developed for veterinary use. It exhibits strong activity against a range of gram-positive and certain gram-negative bacteria, especially respiratory pathogens in ruminants and swine.
Formulated primarily as injectable or oral solutions, Tilmicosin offers extended plasma concentrations after administration, making it a practical choice for mass medication and long-acting treatments in livestock.
Broad-Spectrum Activity
Highly effective against Pasteurella multocida, Mannheimia haemolytica, and Actinobacillus pleuropneumoniae
Extended Action
Long half-life and slow elimination allow for single-dose treatment in many veterinary indications
Veterinary Reliability
Trusted by veterinarians for effective management of respiratory and mycoplasmal infections in livestock
Specification
1. Name and Identification
The active ingredient is Tilmicosin (Veterinary Grade), CAS No. 108050-54-0. It is widely used in the prevention and treatment of respiratory diseases in cattle, pigs, and sheep.
2. Chemical Characteristics
Tilmicosin is a macrolide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. It has a strong affinity for lung tissue and accumulates at the site of infection.
3. Physical Properties
The compound appears as a white to yellowish powder. It is slightly hygroscopic, soluble in organic solvents, and formulated into aqueous solutions or oral premixes.
4. Specifications and Standards
| Test Parameter | Specification |
| Appearance |
Off-white to yellowish crystalline powder |
| Identification A: IR Absorption |
Matches reference spectrum |
| Identification B: Retention Time |
Consistent with standard by HPLC |
| pH Value |
3.5 to 7.5 |
| Specific Rotation |
-45° to -60° (typical of macrolide profile) |
| Crystallinity |
Verified crystalline structure |
| Water Content |
≤ 5.0% (measured by Karl Fischer) |
| Residue on Ignition |
≤ 0.2% |
| Heavy Metals |
≤ 20 ppm |
| Assay |
≥ 70.0% on dry basis |
5. Veterinary Applications
Veterinary Tilmicosin is typically used in the following scenarios:
- Prevention and treatment of bovine respiratory disease (BRD) in feedlot cattle
- Treatment of swine respiratory disease (SRD) caused by Mycoplasma and Pasteurella
- Effective against ovine pneumonic pasteurellosis
- Available as injectable solutions and premixed oral forms
- Commonly used in large-scale operations due to ease of administration and reliable results
Properties
Pharmacological Properties in Animal Systems
Tilmicosin (Veterinary Grade) is a macrolide antibiotic used for its long-acting and targeted effect in veterinary respiratory disease management:
- Mechanism of Action: Inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, effectively halting cell growth.
- Spectrum of Activity: Effective against Mycoplasma, Pasteurella multocida, Mannheimia haemolytica, and Actinobacillus pleuropneumoniae.
- Pharmacokinetics in Animals: Rapidly absorbed and accumulates in lung tissues. Prolonged half-life ensures sustained efficacy after a single administration.
- Stability in Formulations: Stable in both injectable and oral formulations under standard storage conditions.
Chemical Properties
- pH in Solution: Typically ranges from 5.5–7.5 depending on the formulation type.
- Thermal Stability: Stable under ambient temperatures; avoid high heat and direct exposure to sunlight.
- Light Sensitivity: Moderate sensitivity; recommended to store in opaque or light-protective packaging.
- Hygroscopicity: Slightly hygroscopic; store in well-sealed containers to maintain integrity.
- Solubility Characteristics: Soluble in organic solvents; variable solubility in water depending on salt form.
Applications in Different Animal Species
Veterinary-grade Tilmicosin is used in the following target species:
- Cattle and Ruminants: Widely used for the prevention and treatment of bovine respiratory disease (BRD).
- Swine: Administered to control swine respiratory disease (SRD) caused by Mycoplasma and Actinobacillus species.
- Poultry: Applied in feed or water for early-stage control of mycoplasmosis and respiratory infections.
- Sheep and Goats: Effective against pneumonic pasteurellosis and bacterial bronchopneumonia.
Quality Control
Quality Control Measures for Veterinary API
Tilmicosin is manufactured under stringent quality control systems to meet veterinary GMP standards and ensure consistent product performance:
Analytical Testing Methods:
- HPLC Testing: Used to verify active content and detect impurities
- Infrared Spectroscopy (IR): Confirms structural identity
- Microbial Limit Testing: Ensures absence of harmful microbial contaminants
- Moisture Content Analysis: Performed to maintain powder stability
- Residual Solvent Testing: Complies with ICH Q3C standards
Veterinary-Specific Quality Assurance:
Manufactured in GMP-approved facilities and supplied with full documentation: COA, MSDS, and batch-level traceability.
Stability and Compliance:
Stability is validated under accelerated and long-term storage conditions in accordance with ICH guidelines. Packaging meets international shipping and handling standards.
Regulatory and Safety:
- Complies with veterinary pharmacopoeia and international GMP standards
- Regular third-party audits and internal QA reviews are conducted
- Fully documented release procedures before dispatch
Packaging & Transportation
We offer moisture-protective packaging and international logistics services to ensure Tilmicosin (Veterinary API) is safely delivered to customers worldwide.
Packaging Options
Veterinary-Grade Packaging
15kg or 25kg fiber drums sealed with double PE liners to preserve product quality.
Packaging complies with international regulations for pharmaceutical ingredients.
Custom labeling and formats are available to suit veterinary manufacturing or local regulatory needs.
Transportation Options
Global Logistics Solutions
Express Shipping: Available for urgent or small-volume orders via DHL, FedEx, or TNT with full tracking support.
Air Freight: Recommended for medium-sized shipments requiring faster delivery timelines.
Sea Freight: The most cost-effective method for bulk quantities, with complete export documentation and packaging compliance.
Dispatch Time: Orders are typically shipped within 2–3 business days after receipt of payment.
Company Certifications
Veterinary Compliance & Accreditation
- Veterinary GMP: Tilmicosin is manufactured in GMP-compliant facilities dedicated to veterinary actives.
- ISO 9001:2015: Certified quality management ensures consistent production standards and traceability.
- ISO 14001:2015: Environmental controls are applied throughout production and packaging processes.
- Document Readiness: Includes COA, MSDS, batch traceability, and export documentation for customs clearance.
Veterinary GMP
ISO 9001:2015
ISO 14001:2015
FAQ
Frequently Asked Questions About Tilmicosin
Q1: Can I get a sample of Tilmicosin?
A: Yes, we provide free samples for testing. The shipping cost will be borne by the customer.Samples are available for laboratory validation purposes.
Q2: What is the primary veterinary use of Tilmicosin?
A: Tilmicosin is mainly used for treating respiratory infections in cattle, swine, sheep, and poultry.
Q3: What is the product's shelf life?
A: The shelf life is typically 24 months when stored in sealed packaging under recommended conditions.We handle customs clearance in most countries including Southeast Asia and the Middle East
Q4: Can you provide DDP delivery?
A: Yes, we support DDP shipments based on order volume and destination country.We also support GMP certificate submission upon request.
Q5: What documents do you provide with the shipment?
A: Each shipment includes COA, MSDS, packing list, invoice, and regulatory documents for veterinary APIs.
Q6: Is Tilmicosin safe for poultry use?
A: Butaphosphan has been proven safe for use in various animal species including livestock, poultry, and companion animals when used as directed. However, specific dosing should be determined by veterinary professionals based on the target species and application.
Q7: What is the withdrawal time for Tilmicosin in poultry?
A: Yes, Tilmicosin is widely used in poultry under veterinary supervision, especially for treating chronic respiratory disease (CRD) caused by Mycoplasma gallisepticum.
Q8: How does Tilmicosin work?
A: Tilmicosin inhibits protein synthesis in susceptible bacteria by binding to the 50S ribosomal subunit, exerting a bacteriostatic effect.
Q9: Can Tilmicosin be used together with other antibiotics?
A: Tilmicosin should not be used in combination with other macrolides or lincosamides due to potential antagonism. Please consult your vet before co-administration.
Q10: What is the difference between Tilmicosin and Tylosin?
A: Both are macrolide antibiotics, but Tilmicosin has a longer half-life and is more effective for respiratory infections in cattle and poultry. Tylosin is more commonly used in feed-grade formulations.
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